Thermo Scientific Chemicals

Bafilomycin A1, Thermo Scientific Chemicals

製品番号(カタログ番号): J61835.MCR
Each
Thermo Scientific Chemicals

Bafilomycin A1, Thermo Scientific Chemicals

製品番号(カタログ番号): J61835.MCR
Each
製品番号(カタログ番号): J61835.MCR
または、製品番号J61835-M^

化学物質識別子

CAS
88899-55-2
IUPAC Name
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular Formula
C35H58O9
InChI Key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILES
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
Appearance (Color)
White
Assay (HPLC)
95.0% min.
Form
Solid or film

概要

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
• It is a macrolide antibiotic, and shows fungicide activity
Application
• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
• It can be immunosuppressive
• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

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