Chromomycin A3, 97%

CAS: 7059-24-7 | C57H82O26 | 1183.257 g/mol

製品番号（カタログ番号）	数量
J62927.MA または、製品番号J62927-MA	10 mg

製品番号（カタログ番号） J62927.MA

または、製品番号J62927-MA

価格（JPY）

10 mg

一括またはカスタム形式をリクエストする

化学物質識別子

CAS7059-24-7

IUPAC Name(2R,3S,4R,6S)-6-{[(6S,7S)-6-{[(2S,4R,5R,6R)-4-{[(2S,4R,5R,6R)-4-{[(2S,4S,5S,6S)-5-(acetyloxy)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-5,6,7,8-tetrahydroanthracen-2-yl]oxy}-4-{[(2R,4R,5R,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy}-2-methyloxan-3-yl acetate

Molecular FormulaC57H82O26

InChI KeyZYVSOIYQKUDENJ-WKSBCEQHSA-N

SMILESCO[C@@H]([C@@H]1CC2=CC3=CC(O[C@H]4C[C@@H](O[C@@H]5C[C@@H](O)[C@@H](OC)[C@@H](C)O5)[C@@H](OC(C)=O)[C@@H](C)O4)=C(C)C(O)=C3C(O)=C2C(=O)[C@H]1O[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](O)[C@@H](C)O2)[C@H](O)[C@@H](C)O1)C(=O)[C@@H](O)[C@@H](C)O

さらに表示

Appearance (Color)Yellow

FormPowder or crystals or crystalline powder

Assay from Supplier's CofA≥96.0%

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate G-C box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate ″G-C&Pr

RUO – Research Use Only

General References:

CT Amemiya.;JR Gold. Chromomycin A3 stains nucleolus organizer regions of fish chromosomes. Copeia. 19861986 (1), 226-231.
RH Jensen. Chromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples. Journal of Histochemistry & Cytochemistry. 197725 (7), 573-579.