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Thermo Scientific Chemicals
Forskolin, 98+%
Forskolin, CAS # 66575-29-9, is a diterpenoid compound isolated from Indian Coleus that acts as a strong activator of the adenylate cyclase system. | CAS: 66575-29-9 | C22H34O7 | 410.507 g/mol
化学物質識別子
CAS66575-29-9
IUPAC Name(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate
Molecular FormulaC22H34O7
InChI KeyOHCQJHSOBUTRHG-KGGHGJDLSA-N
SMILESCC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]2(O)C(=O)C[C@@](C)(O[C@]12C)C=C
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仕様
スペックシート
スペックシートAppearance (Color)White
Assay from Supplier's CofA≥98.0% (HPLC)
FormPowder
Proton NMRConforms to structure
Forskolin acts as an adenylyl cyclase activator. It is used in the treatment of hypertension, asthma, eczema, psoriasis, congestive heart failure, angina, stomachache, gastric and intestinal spasm. It also plays an important role in the treatment of rheumatism, heart, blood and circulation conditions and cancers. It is used to induce menstruation and as an oral contraceptive.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Forskolin is a diterpenoid and cyclic ketone, found naturally as a plant metabolite
• It is a protein kinase A agonist and a cyclic ketone • Forskolin is an antihypertensive and muscle relaxant; it can also promote the release of pituitary hormones and prevent platelet aggregation
Application
• Forskolin assists in neuron differentiation in vitro
• Useful for studies of cell metabolism and development; there is some evidence of its usefulness in the study of glaucoma
• It is intended for cell culture and biochemistry applications
RUO – Research Use Only
General References:
- Adornetto A, Rombolà L, Morrone LA, Nucci C, Corasaniti MT, Bagetta G, Russo R. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020 Oct 16;12(10):3158. doi: 10.3390/nu12103158. PMID: 33081127; PMCID: PMC7602834.
- Itami T, Hanazono K, Oyama N, Sano T, Makita K, Yamashita K. Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: A dose-response study. PLoS One. 2019 Jul 10;14(7):e0213414. doi: 10.1371/journal.pone.0213414. PMID: 31291253; PMCID: PMC6619603.