G418 disulfate, 50mg/ml solution

Name: G418 disulfate, 50mg/ml solution
SKU: J63871.AB

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic. | CAS: 108321-42-2 | C20H44N4O18S2 | 692.70 g/mol

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数量:

10 mL

50 mL

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製品番号（カタログ番号） J63871.AB

または、製品番号J63871-AB

価格（JPY）

数量:

10 mL

一括またはカスタム形式をリクエストする

化学物質識別子

CAS108321-42-2

IUPAC Name(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)

Molecular FormulaC20H44N4O18S2

InChI KeyUHEPSJJJMTWUCP-KETIWVBHNA-N

SMILESOS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

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仕様

スペックシート

Appearance (Color)Clear colorless

AbsorbanceA570 nm: ≤0.10

Potency≥700 µg/mg

FormLiquid

Absorbanceat 280 nm: ≤0.015

G418 disulfate is used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene. Optimal concentrations for selection and maintenance vary by cell lines.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
G418 is bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

G418 sulfate can be used for the selection of genetically engineered cells in both eukaryotes and prokaryotes
Laboratory-grade for applications such as biochemistry

RUO – Research Use Only

General References:

Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.