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Thermo Scientific Chemicals
3-Isobutyl-1-methylxanthine
CAS: 28822-58-4 | C10H14N4O2 | 222.25 g/mol
| 製品番号（カタログ番号） | 数量 |
|---|---|
| J64598.MC または、製品番号J64598-MC | 100 mg |
化学物質識別子
CAS28822-58-4
IUPAC Name1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Molecular FormulaC10H14N4O2
InChI KeyAPIXJSLKIYYUKG-UHFFFAOYSA-N
SMILESCC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O
さらに表示
スペックシート3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction.
3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction.
RUO – Research Use Only
General References:
- Stephen C. Mann.; Paul A. Andrews.; Stephen B. Howell. Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells. International Journal of Cancer. 1991, 48, (6), 866-872.
- Friedman, G.; Chajek-Shaul, T.; Stein, O.; Stein, Y. Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic amp, cholera toxin and 3-isobutyl- 1-methylxanthine. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 752, (1), 106-117.