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Thermo Scientific Chemicals
Mupirocin, 92%
CAS: 12650-69-0 | C26H44O9 | 500.629 g/mol
化学物質識別子
CAS12650-69-0
IUPAC Name9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid
Molecular FormulaC26H44O9
InChI KeyMINDHVHHQZYEEK-HBBNESRFSA-N
SMILESC[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]1CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O
さらに表示
仕様
スペックシート
スペックシートpH3.5 to 4.5, saturated aqueous solution
Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
Solubility
Soluble in DMSO or methanol. Sparingly soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.Typical working concentrations are in the range of 0.25µg/mL-0.39µg/mL.
Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
Solubility
Soluble in DMSO or methanol. Sparingly soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.Typical working concentrations are in the range of 0.25µg/mL-0.39µg/mL.
RUO – Research Use Only
General References:
- Andrew E Simor; Tammy L Stuart; Lisa Louie; Christine Watt; Marianne Ofner-Agostini; Denise Gravel; Michael Mulvey; Mark Loeb; Allison McGeer; Elizabeth Bryce; Anne Matlow. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrobial Agents and Chemotherapy. 2007, 51, (11), 3880-3886.
- Gaston H.M. Vondenhoff; Arthur Van Aerschot. Aminoacyl-tRNA synthetase inhibitors as potential antibiotics. European Journal of Medicinal Chemistry. 2011, 46, (11), 5227-5236.