Latrunculin A

ラトルングロブリンAは、1：1複合体中の単量体Gアクチンにサブミクロモル濃度で結合することで、培養細胞のマイクロフィラメント組織を破壊します。その生理学的効果には、受精の阻害、初期胚発生、および免疫複合体の食作用の内在化が含まれます。詳細を見る

製品番号（カタログ番号）	数量
L12370	100 μg

製品番号（カタログ番号） L12370

価格（JPY）

134,100

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100 μg

ラトルングロブリンAは、1：1複合体中の単量体Gアクチンにサブミクロモル濃度で結合することで、培養細胞のマイクロフィラメント組織を破壊します。その生理学的効果には、受精の阻害、初期胚発生、および免疫複合体の食作用の内在化が含まれます。

研究用にのみ使用できます。診断用には使用いただけません。

分子式C22H31NO5S

数量100 μg

推奨保存方法フリーザー（-5℃～-30℃）に保存

出荷条件室温

細胞内局在アクチン、細胞骨格

物理的フォームSolid

製品タイプラトランクリンA

Unit SizeEach

引用および参考文献 (336)

引用および参考文献

Abstract

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.

Authors:Cao TT,Deacon HW,Reczek D,Bretscher A,von Zastrow M

Journal:Nature

PubMed ID:10499588

Caveolin-associated filamentous actin (Cav-actin) defines a novel F-actin structure in adipocytes.

Authors:Kanzaki M, Pessin JE

Journal:J Biol Chem

PubMed ID:12039946

Dynamic actin remodeling has been implicated in the translocation of the insulin-responsive glucose transporter 4 (GLUT4) to the plasma membrane in adipocytes. Here we show that fully differentiated 3T3L1 adipocytes have unique cortical filamentous actin structure, designated Cav-actin (caveolae-associated F-actin). During 3T3L1 adipocyte differentiation, rhodamine-phalloidin staining demonstrated the formation of ... More

Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain.

Authors:Yarmola EG, Edison AS, Lenox RH, Bubb MR

Journal:J Biol Chem

PubMed ID:11294839

We recently identified conformational changes that occur upon phosphorylation of myristoylated alanine-rich protein kinase C substrate (MARCKS) that preclude efficient cross-linking of actin filaments (Bubb, M. R., Lenox, R. H., and Edison, A. S. (1999) J. Biol. Chem. 274, 36472-36478). These results implied that the phosphorylation site domain of MARCKS ... More

Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts.

Authors:Hung RJ, Hsu IaW, Dreiling JL, Lee MJ, Williams CA, Oberst MD, Dickson RB, Lin CY

Journal:Am J Physiol Cell Physiol

PubMed ID:15075215

Sphingosine 1-phosphate (S1P), a bioactive phospholipid, simultaneously induces actin cytoskeletal rearrangements and activation of matriptase, a membrane-associated serine protease in human mammary epithelial cells. In this study, we used a monoclonal antibody selective for activated, two-chain matriptase to examine the functional relationship between these two S1P-induced events. Ten minutes after ... More

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier.

Authors:Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA

Journal:Neuron

PubMed ID:11343648

'Na(v)1.6 is the main sodium channel isoform at adult nodes of Ranvier. Here, we show that Na(v)1.2 and its beta2 subunit, but not Na(v)1.6 or beta1, are clustered in developing central nervous system nodes and that clustering of Na(v)1.2 and Na(v)1.6 is differentially controlled. Oligodendrocyte-conditioned medium is sufficient to induce ... More

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