Diethyl (bromodifluoromethyl)phosphonate, 97%
Diethyl (bromodifluoromethyl)phosphonate, 97%
Diethyl (bromodifluoromethyl)phosphonate, 97%
Diethyl (bromodifluoromethyl)phosphonate, 97%
Thermo Scientific Chemicals

Diethyl (bromodifluoromethyl)phosphonate, 97%

CAS: 65094-22-6 | C5H10BrF2O3P | 267.01 g/mol
製品番号(カタログ番号) L16715.14
または、製品番号L16715-14
価格(JPY)
-
見積もりを依頼する
数量:
25 g
一括またはカスタム形式をリクエストする
化学物質識別子
CAS65094-22-6
IUPAC Namediethyl (bromodifluoromethyl)phosphonate
Molecular FormulaC5H10BrF2O3P
InChI KeyQRADKVYIJIAENZ-UHFFFAOYSA-N
SMILESCCOP(=O)(OCC)C(F)(F)Br
さらに表示
Appearance (Color)Clear colorless to pale yellow
FormLiquid
Assay (GC)≥96.0%
Refractive Index1.4150-1.4190 @ 20°C
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Solubility
Not miscible or difficult to mix in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.
RUO – Research Use Only

General References:

  1. Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.
  2. Katherine A Rawls.; Christoph Grundner.; Jonathan A Ellman. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 2010, 8 (18), 4066-4070.