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Thermo Scientific Chemicals
Spermine, 97%
CAS: 71-44-3 | C10H26N4 | 202.35 g/mol
化学物質識別子
CAS71-44-3
IUPAC Name(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
Molecular FormulaC10H26N4
InChI KeyPFNFFQXMRSDOHW-UHFFFAOYSA-N
SMILESNCCCNCCCCNCCCN
さらに表示
仕様
スペックシート
スペックシートFormCrystals or powder or crystalline powder or fused/lumpy solid
Water Content (Karl Fischer Titration)≤1.0%
Identification (FTIR)Conforms (non-U.S. specification)
Appearance (Color)White
Assay (GC)≥96.0%
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
Solubility
Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Notes
Air sensitive and hygroscopic. Store in a cool place. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
Solubility
Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Notes
Air sensitive and hygroscopic. Store in a cool place. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.
RUO – Research Use Only
General References:
- Bailey, D.; Kirby, B. P.; Atkinson, J.; Fixon-Owoo, S.; Henman, M. C.; Shaw, G. G.; Doyle, K. M. Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation. Pharmacol. Biochem. Behav. 2015, 133, 57-64.
- Mo, H.; Wang, X.; Zhang, Y.; Zhang, G.; Zhang, J.; Ma, Z. Cotton polyamine oxidase is required for spermine and camalexin signalling in the defence response to Verticillium dahliae. Plant J. 2015, 83 (6), 962-975.