Ca2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator.
Authors:Tanaka K, Khiroug L, Santamaria F, Doi T, Ogasawara H, Ellis-Davies GC, Kawato M, Augustine GJ
Journal:Neuron
PubMed ID:17553426
Photolysis of a caged Ca(2+) compound was used to characterize the dependence of cerebellar long-term synaptic depression (LTD) on postsynaptic Ca(2+) concentration ([Ca(2+)](i)). Elevating [Ca(2+)](i) was sufficient to induce LTD without requiring any of the other signals produced by synaptic activity. A sigmoidal relationship between [Ca(2+)](i) and LTD indicated a ... More
Ca2+ and Mg2+ binding properties of GCAP-1. Evidence that Mg2+-bound form is the physiological activator of photoreceptor guanylyl cyclase.
Authors:Peshenko IV, Dizhoor AM
Journal:J Biol Chem
PubMed ID:16793776
Guanylyl cyclase-activating protein 1 (GCAP-1) is an EF-hand protein that activates retinal guanylyl cyclase (RetGC) in photoreceptors at low free Ca2+ in the light and inhibits it in the dark when Ca2+ concentrations rise. We present the first direct evidence that Mg2+-bound form of GCAP-1, not its cation-free form, is ... More
Architecture of the mitochondrial calcium uniporter.
Authors:
Journal:Nature
PubMed ID:27135929
Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment.