Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood. One candidate mechanism, given the well-established role of mitochondria in calcium buffering, is a deficit in neuronal calcium homoeostasis. We therefore examined calcium responses in ... More
Second harmonic and sum frequency generation imaging of fibrous astroglial filaments in ex vivo spinal tissues.
Authors:Fu Y, Wang H, Shi R, Cheng JX
Journal:Biophys J
PubMed ID:17293404
Sum frequency generation (SFG) and second harmonic generation (SHG) were observed from helical fibrils in spinal cord white matter isolated from guinea pigs. By combining SFG with coherent anti-Stokes Raman scattering microscopy, which allows visualization of myelinated axons, these fibers were found to be distributed near the surface of the ... More
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.