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Citations & References (29)
Invitrogen™
Paclitaxel, Oregon Green™ 488 Conjugate (Oregon Green™ 488 Taxol, Flutax-2)
このOregon Green 488パクリタキセル誘導体は、生細胞中のチューブリンフィラメントを標識するための重要なプローブとなることが保証されています。この新しいプローブの蛍光ラベルは、プローブを微小管に選択的に結合させる戦略であるパクリタキセルの7-Carbonに貼付されています。研究者は、さまざまなシステムで同様の蛍光パクリタキセル誘導体を使用しています。詳細を見る
| 製品番号（カタログ番号） | 数量 |
|---|---|
| P22310 | 100 μg |
製品番号（カタログ番号） P22310
価格（JPY）お問い合わせください ›
114,000
Each
数量:
100 μg
このOregon Green 488パクリタキセル誘導体は、生細胞中のチューブリンフィラメントを標識するための重要なプローブとなることが保証されています。この新しいプローブの蛍光ラベルは、プローブを微小管に選択的に結合させる戦略であるパクリタキセルの7-Carbonに貼付されています。研究者は、さまざまなシステムで同様の蛍光パクリタキセル誘導体を使用しています。
研究用にのみ使用できます。診断用には使用いただけません。
仕様
染色剤タイプOregon Green™ 488
製品ラインOregon Green
数量100 μg
出荷条件室温
標識タイプ従来の色素
製品タイプパクリタキセル
SubCellular Localizationチューブリン, 細胞骨格, Tubulin
Unit SizeEach
組成および保存条件
フリーザー(-5°C∼-30°C)に保存し、遮光してください。
引用および参考文献 (29)
引用および参考文献
Abstract
The interaction of baccatin III with the taxol binding site of microtubules determined by a homogeneous assay with fluorescent taxoid.
Journal:Biochemistry
PubMed ID:11580273
'The ubiquitous Taxol binding site of microtubules also binds newly discovered ligands. We have designed a homogeneous assay for the high throughput detection of Taxol biomimetics, based on the displacement of 7-O-[N-(2,7-difluoro-4''-fluoresceincarbonyl)-L-alanyl]Taxol from its binding site in diluted solutions of preserved microtubules. The state of this reference ligand is measured
An incremental approach to automated protein localisation.
Journal:BMC Bioinformatics
PubMed ID:18937856
'BACKGROUND: The subcellular localisation of proteins in intact living cells is an important means for gaining information about protein functions. Even dynamic processes can be captured, which can barely be predicted based on amino acid sequences. Besides increasing our knowledge about intracellular processes, this information facilitates the development of innovative
Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site.
Journal:J Biol Chem
PubMed ID:10818101
'We have determined the kinetic scheme and the reaction rates of binding to microtubules of two fluorescent taxoids, 7-O-[N-(4''-fluoresceincarbonyl)-l-alanyl]Taxol (Flutax-1) and 7-O-[N-(2,7-difluoro-4''-fluoresceincarbonyl)-l-alanyl]Taxol (Flutax-2). Flutax-1 and Flutax-2 bind to microtubules with high affinity (K(a) approximately 10(7) m(-1), 37 degrees C). The binding mechanism consists of a fast bimolecular reaction followed by
Fluorescent taxoid probes for microtubule research.
Journal:Methods Cell Biol
PubMed ID:20466144
'The use of the antitumor drug taxol as an experimental microtubule-stabilizing agent is widespread. Fluorescent taxol conjugates, although less employed, are very useful tools for several purposes in microtubule research. These include easily visualizing microtubule cytoskeletons in a variety of cells as well as in vitro assembled microtubules, studying the
Perspective of a new diagnostic for human trichomonosis.
Journal:Mem Inst Oswaldo Cruz
PubMed ID:12764446
Several diagnostic techniques have been employed for the detection of Trichomonas vaginalis. Microtubules constitute the cytoskeleton in eukaryotic cells and are sensitive to antimitotic drugs, such as Taxol (paclitaxel). We used FLUTAX a fluorescent taxoid - to analyze the microtubule distribution in living trophozoites of T. vaginalis in urine and