Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.
Authors:Gillard GO, Farr AG
Journal:J Immunol
PubMed ID:16670287
'Although putative thymic epithelial progenitor cells have been identified, the developmental potential of these cells, the extent of medullary thymic epithelium (mTEC) heterogeneity, and the mechanisms that mediate the expression of a wide range of peripheral tissue-restricted Ags (TRAs) by mTECs remain poorly defined. Here we have defined several basic ... More
Diversity of human small intestinal Streptococcus and Veillonella populations.
Authors:van den Bogert B, Erkus O, Boekhorst J, de Goffau M, Smid EJ, Zoetendal EG, Kleerebezem M
Journal:FEMS Microbiol Ecol
PubMed ID:23614882
'Molecular and cultivation approaches were employed to study the phylogenetic richness and temporal dynamics of Streptococcus and Veillonella populations in the small intestine. Microbial profiling of human small intestinal samples collected from four ileostomy subjects at four time points displayed abundant populations of Streptococcus spp. most affiliated with S. salivarius, S. thermophilus, ... More
Rediscovery of the Yesso scallop pathogen Perkinsus qugwadi in Canada, and development of PCR tests.
Authors:Itoh N, Meyer GR, Tabata A, Lowe G, Abbott CL, Johnson SC
Journal:
PubMed ID:23670082
'Perkinsus qugwadi, a pathogenic protozoan parasite of Yesso scallops Patinopecten yessoensis, is found only in cultured populations in British Columbia, Canada. This pathogen was first identified in 1988 and caused significant mortalities at some locations during the early 1990s. Prevalence of infection decreased dramatically following 1995, and the disease was ... More
Temporal role of Sertoli cell androgen receptor expression in spermatogenic development.
Authors:Hazra R, Corcoran L, Robson M, McTavish KJ, Upton D, Handelsman DJ, Allan CM
Journal:Mol Endocrinol
PubMed ID:23160479
'Sertoli cell (SC) androgen receptor (AR) activity is vital for spermatogenesis. We created a unique gain-of-function transgenic (Tg) mouse model to determine the temporal role of SCAR expression in testicular development. The SC-specific rat Abpa promoter directed human Tg AR [Tg SC-specific AR (TgSCAR)] expression, providing strong premature postnatal AR ... More
P-glycoprotein in sheep liver and small intestine: gene expression and transport efflux activity.
Authors:Ballent M, Wilkens MR, Maté L, Muscher AS, Virkel G, Sallovitz J, Schröder B, Lanusse C, Lifschitz A
Journal:J Vet Pharmacol Ther
PubMed ID:23409949
'The role of the transporter P-glycoprotein (P-gp) in the disposition kinetics of different drugs therapeutically used in veterinary medicine has been demonstrated. Considering the anatomo-physiological features of the ruminant species, the constitutive expression of P-gp (ABCB1) along the sheep gastrointestinal tract was studied. Additionally, the effect of repeated dexamethasone (DEX) ... More