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          System Message

          OKCancel
          LOADING ...
          See other PSEN1 SIRNA Assays ›
          Gene Symbol:
          PSEN1
          Gene Name:
          presenilin 1
          Gene Aliases:
          AD3, FAD, PS-1, PS1, S182
          Chromosome Location:
          Chr.14: 73136435 - 73223691 on Build GRCh38
          UniGene ID:
          Hs.3260
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID 2612

          Purification
          Size
          Availability Inventoried
          Catalog # AM16708
          Price 4,126.00
          Your Price
          Online offer:
          4126.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: PSEN1
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_000021.3 NP_000012.1 4, 5 619
          NM_007318.2 NP_015557.2 4, 5 607
          XM_005267864.2 XP_005267921.1 4, 5 613
          XM_005267866.1 XP_005267923.1 4, 5 602
          XM_011536971.2 XP_011535273.1 4, 5 511
          XM_011536972.2 XP_011535274.1 4, 5 875
          XM_011536973.1 XP_011535275.1 4, 5 863
          XM_011536974.1 XP_011535276.1 4, 5 504
          GenBank mRNA AF416717.1 - 2, 3 335
          AJ008005.1 - 4, 5 553
          AK122722.1 - 2, 3 1888
          AK223173.1 - 2, 3 349
          AK312531.1 - 4, 5 603
          BC011729.2 - 4, 5 588 4423098
          KU178285.1 - 2, 3 323
          KU178286.1 - 2, 3 335
          L42110.1 - 4, 5 583
          L76517.1 - 4, 5 876
          U40379.1 - 2, 3 323
          U40380.1 - 2, 3 323

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Rat: NM_019163, XM_006240321, XM_006240322, D82363, BC070887, and others.

          Panther Classification:

          Molecular Function -

          aspartic protease

          Gene Ontology Categories:

          Function(s) Process(es)

          autophagosome assembly
          negative regulation of transcription from RNA polymerase II promoter
          activation of MAPKK activity
          blood vessel development
          cell fate specification
          somitogenesis
          neuron migration
          positive regulation of receptor recycling
          heart looping
          hematopoietic progenitor cell differentiation
          T cell activation involved in immune response
          neural retina development
          protein glycosylation
          membrane protein ectodomain proteolysis
          mitochondrial transport
          cellular response to DNA damage stimulus
          response to oxidative stress
          negative regulation of epidermal growth factor-activated receptor activity
          Notch signaling pathway
          Notch receptor processing
          memory
          post-embryonic development
          protein transport
          L-glutamate transport
          choline transport
          synaptic vesicle targeting
          single organismal cell-cell adhesion
          protein processing
          cerebral cortex cell migration
          Cajal-Retzius cell differentiation
          dorsal/ventral neural tube patterning
          embryonic limb morphogenesis
          positive regulation of proteasomal ubiquitin-dependent protein catabolic process
          endoplasmic reticulum calcium ion homeostasis
          beta-amyloid formation
          intracellular signal transduction
          regulation of phosphorylation
          amyloid precursor protein catabolic process
          myeloid dendritic cell differentiation
          positive regulation of apoptotic process
          negative regulation of apoptotic process
          positive regulation of catalytic activity
          regulation of protein binding
          positive regulation of MAP kinase activity
          negative regulation of neuron apoptotic process
          skin morphogenesis
          positive regulation of transcription, DNA-templated
          regulation of synaptic plasticity
          thymus development
          neuron development
          skeletal system morphogenesis
          brain morphogenesis
          epithelial cell proliferation
          negative regulation of axonogenesis
          positive regulation of coagulation
          T cell receptor signaling pathway
          neuron apoptotic process
          negative regulation of ubiquitin-protein transferase activity
          smooth endoplasmic reticulum calcium ion homeostasis
          regulation of synaptic transmission, glutamatergic
          canonical Wnt signaling pathway
          regulation of resting membrane potential
          positive regulation of dendritic spine development
          calcium ion transmembrane transport
          negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
          negative regulation of apoptotic signaling pathway
          endopeptidase activity
          aspartic-type endopeptidase activity
          calcium channel activity
          protein binding
          beta-catenin binding
          PDZ domain binding
          cadherin binding

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