Thermo Fisher Scientific
At GSK, charged aerosol detection is an established detector for impurities analysis. There is a limitation to the charged aerosol detector running gradient analysis due to the change in solvent composition creating response differences of the analytes over the course of a run which leads to the need to externally standardize the determination of the analytes. At GSK, a custom-built system to compensate for solvent composition changes during gradient.
Thermo Fisher Scientific offers a complete solution that is capable of simultaneously delivering a chromatographic gradient and an inverse gradient.
The development of method and comparison of data generated across the custom-built and ready-made systems was carried out at GSK and details of the work will be presented.
People interested in the analysis of unknown impurities, and anyone being faced with the challenge of how to separate, detect and quantify impurities.
Gemma Sturgeon; Senior Scientist at GSK; PDS CMCA – DS&PA; R&D Medicines, Science and Technology
Gemma has 18 years in the pharmaceutical industry nearly all of that within the R&D framework working mainly on small molecules during this time with two years in biopharmaceuticals. The last six years have been at GSK within Analytical development using her knowledge and expertise to develop and validate methods for late phase projects.
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