The heterogeneous nature of tumor biopsies can make it difficult to generate useful genomic data from whole tissue samples. Laser capture microdissection (LCM) is a powerful technique that has become instrumental to researchers interested in comparing the molecular profiles of tumor tissue to surrounding non-tumor cells, thereby unlocking hidden molecular signatures in individual patient tumor samples and leading the way for tailored treatment and personalized medicine. The gentle IR laser of the ArcturusXT™ LCM system preserves tissue morphology and genetic content of captured and neighboring cells, providing researchers with an effective tool to easily verify captured material while simultaneously preserving biomolecule integrity.
Learn how Dr. Chip Petricoin at the Center for Applied Proteomics and Molecular Medicine at George Mason University discovered, using the ArcturusXT™ LCM System, that pure tumor samples were affected by the unknown and unknowable amounts of stroma and other cells.
Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping.
J Mol Diagn. 2013 Mar;15(2):171-6.
Beadling C, Neff TL, Heinrich MC, Rhodes K, Thornton M, Leamon J, Andersen M, Corless CL.
Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon.
PLoS Genet. 2009 Jan;5(1):e1000334.
Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, Ho SM.