Oncology Research with Laser Capture Microdissection (LCM)

The heterogeneous nature of tumor biopsies can make it difficult to generate useful genomic data from whole tissue samples. Laser capture microdissection (LCM) is a powerful technique that has become instrumental to researchers interested in comparing the molecular profiles of tumor tissue to surrounding non-tumor cells, thereby unlocking hidden molecular signatures in individual patient tumor samples and leading the way for tailored treatment and personalized medicine. The gentle IR laser of the ArcturusXT™ LCM system preserves tissue morphology and genetic content of captured and neighboring cells, providing researchers with an effective tool to easily verify captured material while simultaneously preserving biomolecule integrity.

Sample workflows
LCM to qRT-PCR workflow
Next-generation sequencing starting with FFPE tissue samples
   

Video: Dr. Chip Petricoin

Learn how Dr. Chip Petricoin at the Center for Applied Proteomics and Molecular Medicine at George Mason University discovered, using the ArcturusXT™ LCM System, that pure tumor samples were affected by the unknown and unknowable amounts of stroma and other cells.

Literature