Interact Reference Component

Next-generation sequencing (NGS) is a high-throughput methodology that enables rapid sequencing of the base pairs in DNA or RNA samples. Supporting a broad range of applications, including gene expression profiling, chromosome counting, detection of epigenetic changes, and molecular analysis, NGS is driving discovery and enabling the future of personalized medicine.

Ion Torrent next-generation sequencing systems

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Scalable targeted NGS to support small and large projects
The Ion GeneStudio S5 system is a scalable, targeted-NGS workhorse with wide application breadth and throughput capability.

Ion Torrent Genexus System

Specimen to report in a single day with a hands-off, automated workflow*​
​The Genexus System is the first turnkey NGS solution that automates the specimen-to-report workflow and delivers results in a single day with just two user touchpoints.*​

Targeted NGS applications

Infectious disease and microbial research

From viruses to microbial communities

Reproductive health

From pre-implantation to congenital research

Human identification (HID)

Forensic DNA analysis and phenotyping, from genotyping to STRs to mitochondrial DNA

Agrigenomics

Simple, scalable and affordable NGS for plant and animal genotyping applications

HLA typing

Genotyping Class I and Class II loci

NGS workflow and data management

Streamline your NGS workflow

How does Ion Torrent NGS work?

Ion Torrent next-generation sequencing exploits the fact that addition of a dNTP to a DNA polymer releases a hydrogen ion. We measure the pH change resulting from those hydrogen ions using semiconductors, simultaneously measuring millions of such changes to determine the sequence of each fragment.

The semiconductor approach—unlike optics or modified nucleotides used in other NGS technologies—helps you implement a fast and simple workflow that scales to your research needs across multiple applications including inherited disease, oncology, infectious disease, human identification (HID), human leukocyte antigen (HLA) typing, and agrigenomics.

Our targeted sequencing approach introduces a PCR-based sequence enrichment step using Ion AmpliSeq technology that focuses on genes or even genetic variants of interest; a good example is the targeting of oncogenes and tumor suppressors in a cancer research study.

Learn more about next-generation sequencing ›

Support

Next-Generation Sequencing Support Center
Find tips, troubleshooting help, and resources for your next-generation sequencing applications.

NGS Service Provider Program

*Specimen-to-report workflow available after Ion Torrent Genexus Purification System and integrated report launch in 2020.