The Ion GeneStudio S5 systems are designed to enable a broad range of targeted next-generation sequencing (NGS) applications with speed and scalability. Five Ion S5 chips enable a sequencing throughput range of 2M to 130M reads per run.
As little as 15 minutes hands-on time and same day results.
Ion GeneStudio S5 System
Ion GeneStudio S5 Plus System
Ion GeneStudio S5 Prime System
Max. throughput/day (chip type)
Total sequencing and analysis time at max. throughput
19 hr (Ion 540 Chip)
10 hr (Ion 540 Chip)
6.5 hr (Ion 540 Chip)
Ion 510, 520, 530, 540 chips
Ion 510, 520, 530, 540, and 550 chips
From gene panels to exomes, gene expression profiling to transcriptomes, or microbial genomes to microbiomes, Ion Torrent semiconductor sequencing optimizes cost and throughput for small and large NGS projects.
|Inherited disease research:|
panels for targeted gene or whole exome analysis
Gene expression analysis:
|Reproductive health research:|
aneuploidy detection, carrier screening research
|Microbiology/infectious disease research:|
microbial whole genomes, microbial typing, and metagenomics
Enabling NGS analysis and discovery of multi-biomarker types (fusions, insertion/deletions (indels), single nucleotide variants, and copy number variations), Oncomine assays are part of an end-to-end workflow that includes simple, scalable sequencing with optimized bioinformatics and reporting—designed for cancer research.
Figure 1. Prediction of immunotherapy outcome via TCR evenness and convergence
Approach: Leverage the low substitution error rate of the Ion Torrent platform to evaluate convergence as a predictive biomarker for response to anti-CTLA-4 monotherapy in a set of 22 individuals with cancer. Eight peripheral blood leukocyte (PBL) samples derived from three donors were analyzed using the Oncomine TCRB-LR assay or Sequenta/Adaptive Biotechnologies TCRB assay.
Results: The combination of TCR evenness and convergence improves prediction of response (AUC = .89).
Our complete NGS solutions are uniquely suited to research in understanding how the combination of genetics and the environment influence development of complex diseases such as autoimmune disorders, neurodegenerative diseases, and many others.
Approach: identify causative variants of different inherited cardiomyopathies using a single Ion AmpliSeq gene panel.
Results: Potential pathogenic variants found in 23.6% of study samples including a homozygous variant in the SLC25A4 gene.
Uncover microbial diversity, study pathogen outbreaks, and identify mutations that may be associated with antibiotic resistance. Take advantage of increased throughput, higher accuracy, and longer reads to produce rapid and accurate sequencing of microbes with streamlined sample preparation and a simple, scalable, and optimized data analysis workflow.
Approach: reconstruct the history of the storage of three single statues to infer the relationship among them, and to elucidate their geographical shift using metagenomic analyses of the 16S ribosomal DNA (rDNA) and other analyses
Results: eukaryotic microbiomes showed similarities comprising many soil-inhabiting organisms. Two statues displayed many halotolerant and halophilic bacteria which may indicate a longer stay in arid and semi-arid surroundings as well as marine environments
For Research Use Only. Not for use in diagnostic procedures.