The Ion GeneStudio S5 systems, combined with the Ion Chef automated library and template preparation system, enable a streamlined next-generation sequencing (NGS) workflow for targeted sequencing with flexibility and scalability.

  • Three models that offer a range of sequencing speeds
  • Multiple sequencing chip options that enable the use of one instrument for small and large projects based on your throughput needs
  • An expansive menu of applications covering everything from oncology to reproductive health research

Choose from our fast, faster, or fastest model

The S5, S5 Plus, and S5 Prime models offer different sequencing speeds to meet your lab's need.


For example, when using a 540 chip, sequencing and analysis time on the S5 is 19 hours, the S5 Plus is 10 hours, and the S5 Prime is 6.5 hours.

Sequencing that adjusts to your laboratory’s needs

How can a single instrument seamlessly scale to accommodate multiple applications, throughputs, and data outputs? The answer is in the chip.


Ion Torrent sequencing chips help streamline your workflow while offering flexibility for a wide range of research applications. First, consider the number of samples you need to run and the desired data output that is optimal for your application. Then, simply select a sequencing chip that fits your throughput or application needs, ranging from 2 to 130 million reads per run.


This versatility enables you to run both small‑ and large‑scale projects without the need to change platforms.

Applications for whatever you seek to uncover

Explore the wide range of applications supported by the Ion Torrent NGS Systems.


Cancer research

Enabling NGS analysis and discovery of multi-biomarker types (fusions, insertion/deletions (indels), single nucleotide variants, and copy number variations), Oncomine assays are part of an end-to-end workflow that includes simple, scalable sequencing with optimized bioinformatics and reporting—designed for cancer research.


Reproductive health research

Ion Torrent NGS solutions offer important scientific insight for future reproductive decisions.


Infectious disease and microbial research

Uncover microbial diversity, study pathogen outbreaks, and identify mutations that may be associated with antibiotic resistance. Take advantage of increased throughput, higher accuracy, and longer reads to produce rapid and accurate sequencing of microbes with streamlined sample preparation and a simple, scalable, and optimized data analysis workflow.


Complex and Inherited disease

Our complete NGS solutions are uniquely suited to research in understanding how the combination of genetics and the environment influence development of complex diseases such as autoimmune disorders, neurodegenerative diseases, and many others.


Human identification (HID)

Adopting targeted NGS for forensic DNA analysis and phenotyping in your laboratory is simpler than ever when you combine the Ion Chef System and Ion GeneStudio S5 Systems with optimized Precision ID library preparation, template preparation and sequencing kits, and forensically relevant panels.



Uncover traits to drive breeding decisions and help address the challenges of feeding a growing global population. Our instruments, reagents, and solutions for plant and animal genotyping applications enable simple, scalable, and affordable NGS that can help you drive remarkable agricultural innovations.


Ion AmpliSeq Designer

Don’t see your application listed above? Ion AmpliSeq Designer is an online primer design tool that lets you create custom panels for Ion Torrent next-generation sequencing. Researchers studying germline disorders can use this tool to create Ion AmpliSeq On-Demand panels from a catalog of pre-tested genes and receive them in smaller reaction sizes, so that they can iterate panel design with efficiency and convenience.