Antibodies that detect CD35 can be used in several scientific applications, including Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry and Immunohistochemistry (Frozen). These antibodies target CD35 in Human, Non-human primate, Mouse and Rat samples. Our CD35 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse and Rabbit. These antibodies have been verified by Relative expression to confirm specificity to CD35. Find the CD35 antibody that fits your needs. Choose from 1 of 33 CD35 antibodies, which have been validated in experiments with 11 publications and 65 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.
500 µL
100 µg
200 µg
100 µg
50 µg
100 Tests
7 mL
100 µg
100 µg
100 Tests
100 µg
100 Tests
100 Tests
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