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Carcinoembryonic Antigen (CEA)/CD66 Monoclonal Antibody (C66/1009)

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Carcinoembryonic Antigen (CEA)/CD66 Monoclonal Antibody (C66/1009)

Product Details

1048-MSM5-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

0.5-1 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

C66/1009

Immunogen

Recombinant full-length human CEA protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The CD66 molecules are 180-200 kDa glycoproteins of carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells. The expression of CD66 increases significantly on granulocytes upon their activation. CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the plasma membrane by C-terminal glycosylphosphatidylinositol (GPI) lipid moiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD66; BGP; BGP-1; Biliary glycoprotein 1; biliary glycoprotein adhesion molecule; biliary glycoprotein I precursor; carcinoembronyic antigen; Carcinoembryonic antigen; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen CGM7; carcinoembryonic antigen gene family member 1; carcinoembryonic antigen gene family member 7; carcinoembryonic antigen precursor; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen related cell adhesion molecule 3; carcinoembryonic antigen related cell adhesion molecule 4; carcinoembryonic antigen related cell adhesion molecule 5; carcinoembryonic antigen related cell adhesion molecule 6; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 4; carcinoembryonic antigen-related cell adhesion molecule 4-sv1; carcinoembryonic antigen-related cell adhesion molecule 4-sv2; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66a antigen; CD66c; CD66d; CD66d antigen; CD66e; CEA; CEA cell adhesion molecule 1; CEA cell adhesion molecule 3; CEA cell adhesion molecule 4; CEA cell adhesion molecule 5; CEA cell adhesion molecule 6; CEACAM-1; CEACAM-3; CEACAM-5; CEACAM-6; CEACAM1-3S; Cell adhesion molecule CEACAM1; Cell adhesion molecule CEACAM3; Cell adhesion molecule CEACAM4; Cell adhesion molecule CEACAM5; Cell adhesion molecule CEACAM6; Cluster of Differentiation 66c; Meconium antigen 100; Non-specific cross-reacting antigen W236; Non-specific crossreacting antigen; nonspecific cross-reacting antigen; Nonspecific cross-reacting antigen (NCA); nonspecific cross-reacting antigen W236; nonspecific crossreacting antigen precursor; Normal cross-reacting antigen; ORF1; ORF2; pan CEACAM; unnamed protein product

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Gene Aliases: BGP; BGP1; BGPI; CD66c; CD66D; CD66e; CEA; CEACAM1; CEACAM3; CEACAM4; CEACAM5; CEACAM6; CEAL; CGM1; CGM1a; CGM7; CGM7_HUMAN; NCA; NCA-50/90; W264; W282

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UniProt ID: (Human) P13688, (Human) P40198, (Human) O75871, (Human) P06731, (Human) P40199

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Entrez Gene ID: (Human) 634, (Human) 1084, (Human) 1089, (Human) 1048, (Human) 4680

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Function(s)
actin binding protein binding calmodulin binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding identical protein binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding GPI anchor binding protein heterodimerization activity
Process(es)
apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules positive regulation of cell proliferation positive regulation of cell migration positive regulation of heterotypic cell-cell adhesion positive regulation of endothelial cell-matrix adhesion via fibronectin negative regulation of anoikis regulation of immune system process phagocytosis signal transduction angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity integrin-mediated signaling pathway regulation of endothelial cell migration bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway negative regulation of lipid biosynthetic process regulation of protein kinase B signaling regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion via plasma-membrane adhesion molecules insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis negative regulation of myotube differentiation homotypic cell-cell adhesion negative regulation of apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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