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Proteintech
TRIM21 Polyclonal Antibody
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Product Details
12108-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Hamster,
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRIM21 Fusion Protein Ag2753 (176-475 aa encoded by BC010861)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SRIHAEFVQ QKNFLVEEEQ RQLQELEKDE REQLRILGEK EAKLAQQSQA LQELISELDR RCHSSALELL QEVIIVLERS ESWNLKDLDI TSPELRSVCH VPGLKKMLRT CAVHITLDPD TANPWLILSE DRRQVRLGDT QQSIPGNEER FDSYPMVLGA QHFHSGKHYW EVDVTGKEAW DLGVCRDSVR RKGHFLLSSK SGFWTIWLWN KQKYEAGTYP QTPLHLQVPP CQVGIFLDYE AGMVSFYNIT DHGSLIYSFS ECAFTGPLRP FFSPGFNDGG KNTAPLTLCP LNIGSQGSTD Y (176-475 aa encoded by BC010861)
Target Information
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52-kD Ro/SSA ribonucleoprotein; 52kD Ro/SSA autoantigen; 52kDa ribonucleoprotein autoantigen SS-A/Ro; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Ro/SSA 52kDa; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SS-A; tripartite motif protein 21; Tripartite motif-containing protein 21
Gene Aliases: RNF81; Ro/SSA; RO52; SSA; SSA1; TRIM21
UniProt ID: (Human) P19474
Entrez Gene ID: (Human) 6737, (Mouse) 20821
DNA binding
transcription coactivator activity
RNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
identical protein binding
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
autophagosome assembly
protein polyubiquitination
protein monoubiquitination
I-kappaB kinase/NF-kappaB signaling
regulation of gene expression
proteasomal protein catabolic process
positive regulation of autophagy
protein ubiquitination
protein destabilization
negative regulation of NF-kappaB transcription factor activity
positive regulation of protein binding
regulation of type I interferon production
negative regulation of viral transcription
stress granule assembly
response to interferon-gamma
stress granule disassembly
protein K27-linked ubiquitination
negative regulation by host of viral release from host cell
innate immune response
positive regulation of cell cycle
negative regulation of innate immune response
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
protein autoubiquitination
cellular response to chemical stress
pyroptosis
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of primary metabolic process
protein K6-linked ubiquitination
negative regulation of protein deubiquitination
antiviral innate immune response
positive regulation of NIK/NF-kappaB signaling
cell cycle
positive regulation of sequence-specific DNA binding transcription factor activity
protein trimerization
negative regulation of viral release from host cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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