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Invitrogen
Somatostatin Monoclonal Antibody (ICDCLS), eFluor™ 660, eBioscience™
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FIGURE: 1 / 2
Somatostatin Antibody (50-9751-82) in IHC (P)
Immunohistochemistry of formalin-fixed paraffin embedded human pancreas tissue using 5 µg/mL Anti-Somatostatin eFluor® 660 (white), 10 µg/mL Anti-Glucagon Alexa Fluor® 488 (green), and 0.5 µg/mL Anti-Insulin eFluor® 570 (red). Nuclei are stained with DAPI (blue).
Product Details
50-9751-82
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
ICDCLS
Conjugate
Excitation/Emission Max
651/668 nm
View spectra
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin. Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or somatotrophin release-inhibiting factor (SRIF), is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein. Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas as well as by the hypothalamus and intestine. Somatostatin has a variety of functions, such as regulating the endocrine system and affecting neurotransmission and cell proliferation. Somatostatin also inhibits the release of numerous secondary hormones, such as insulin and glucagon. Somatostatin can be used to identify medium size aspiny neurons in the striatum, cortex, and hippocampus. Expression of somatostatin is present in hyperplasia of the pancreatic islets as well as islet cell tumors such as somatostatinomas.
Applications Reported: This ICDCLS antibody has been reported for use in microscopy and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.
Applications Tested: This ICDCLS antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.
Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Growth hormone release-inhibiting factor; prepro-somatostatin; preprosomatostatin; Somatostatin; somatostatin 28; somatostatin-14; somatostatin-28; somatotropin release-inhibiting factor; SRIF; unnamed protein product
Gene Aliases: SMST; SOM; SRIF; SS; SS-14; SS-28; SST; SST1
UniProt ID: (Human) P61278, (Mouse) P60041, (Rat) P60042
Entrez Gene ID: (Human) 6750, (Mouse) 20604, (Rat) 24797
hyperosmotic response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
chemical synaptic transmission
response to nutrient
digestion
negative regulation of cell proliferation
hormone-mediated apoptotic signaling pathway
response to xenobiotic stimulus
response to acidic pH
regulation of cell migration
somatostatin signaling pathway
response to amino acid
response to steroid hormone
regulation of postsynaptic membrane neurotransmitter receptor levels
response to heat
response to organonitrogen compound
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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