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Proteintech
GOT1 Monoclonal Antibody (5A12E10)
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Product Details
60317-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5A12E10
Immunogen
GOT1 Fusion Protein Ag7012 (1-413 aa encoded by BC000498)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAPPSVFAE VPQAQPVLVF KLTADFREDP DPRKVNLGVG AYRTDDCHPW VLPVVKKVEQ KIANDNSLNH EYLPILGLAE FRSCASRLAL GDDSPALKEK RVGGVQSLGG TGALRIGADF LARWYNGTNN KNTPVYVSSP TWENHNAVFS AAGFKDIRSY RYWDAEKRGL DLQGFLNDLE NAPEFSIVVL HACAHNPTGI DPTPEQWKQI ASVMKHRFLF PFFDSAYQGF ASGNLERDAW AIRYFVSEGF EFFCAQSFSK NFGLYNERVG NLTVVGKEPE SILQVLSQME KIVRITWSNP PAQGARIVAS TLSNPELFEE WTGNVKTMAD RILTMRSELR ARLEALKTPG TWNHITDQIG MFSFTGLNPK QVEYLVNEKH IYLLPSGRIN VSGLTTKNLD YVATSIHEAV TKIQ (1-413 aa encoded by BC000498)
Target Information
GOT1 is a glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aspartate aminotransferase; aspartate aminotransferase 1; Aspartate aminotransferase, cytoplasmic; aspartate transaminase 1; cAspAT; cCAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); growth-inhibiting protein 18; testis secretory sperm-binding protein Li 196a; Transaminase A; unnamed protein product
Gene Aliases: AI789014; Aspat; AST; AST1; ASTQTL1; cAspAT; cCAT; Gaspat; GIG18; Got-1; GOT1; SGOT
UniProt ID: (Human) P17174, (Chicken) P00504, (Rat) P13221, (Mouse) P05201
Entrez Gene ID: (Human) 2805, (Chicken) 396261, (Rat) 24401, (Mouse) 14718
catalytic activity
L-aspartate:2-oxoglutarate aminotransferase activity
phosphatidylserine decarboxylase activity
protein binding
transaminase activity
transferase activity
pyridoxal phosphate binding
carboxylic acid binding
L-cysteine:2-oxoglutarate aminotransferase activity
L-phenylalanine:2-oxoglutarate aminotransferase activity
transaminase
gluconeogenesis
2-oxoglutarate metabolic process
oxaloacetate metabolic process
glycerol biosynthetic process
cellular amino acid metabolic process
aspartate metabolic process
aspartate biosynthetic process
aspartate catabolic process
glutamate metabolic process
Notch signaling pathway
cellular amino acid biosynthetic process
response to carbohydrate
glutamate catabolic process to aspartate
positive regulation of transforming growth factor beta receptor signaling pathway
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
response to immobilization stress
malate-aspartate shuttle
dicarboxylic acid metabolic process
response to cadmium ion
response to glucocorticoid
negative regulation of cytosolic calcium ion concentration
negative regulation of mitochondrial depolarization
fatty acid homeostasis
transdifferentiation
cellular response to mechanical stimulus
L-glutamate biosynthetic process
response to transition metal nanoparticle
glutamate catabolic process to 2-oxoglutarate
biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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