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Proteintech
NRF1 Monoclonal Antibody (3C2B8)
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Product Details
66832-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3C2B8
Immunogen
NRF1 Fusion Protein Ag28149 (213-522 aa encoded by BC016925)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LKYSTGRGK PGWGKESCKP IWWPEDIPWA NVRSDVRTEE QKQRVSWTQA LRTIVKNCYK QHGREDLLYA FEDQQTQTQA TATHSIAHLV PSQTVVQTFS NPDGTVSLIQ VGTGATVATL ADASELPTTV TVAQVNYSAV ADGEVEQNWA TLQGGEMTIQ TTQASEATQA VASLAEAAVA ASQEMQQGAT VTMALNSEAA AHAVATLAEA TLQGGGQIVL SGETAAAVGA LTGVQDANGL FMADRAGRKW ILTDKATGLV QIPVSMYQTV VTSLAQGNGP VQVAMAPVTT RISDSAVTMD GQAVEVVTLE Q (213-522 aa encoded by BC016925)
Target Information
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1; nuclear respiratory factor-1; unnamed protein product
Gene Aliases: ALPHA-PAL; C87038; D6Ertd415e; Nfe2l1_retired; NRF1
UniProt ID: (Human) Q16656, (Mouse) Q9WU00
Entrez Gene ID: (Human) 4899, (Rat) 312195, (Mouse) 18181
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
DNA-binding transcription factor
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
transcription, DNA-templated
mitochondrion organization
organ regeneration
response to estradiol
response to lipopolysaccharide
response to folic acid
response to electrical stimulus
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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