Proteintech

VPS4B Monoclonal Antibody (2H3G7)

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VPS4B Monoclonal Antibody (2H3G7)

Product Details

68443-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-

Immunocytochemistry (ICC/IF)

1:400-1:1,600
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

0.5-4.0 µg for 1.0-3.0 mg of total protein lysate
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2H3G7

Immunogen

VPS4B fusion protein Ag11610
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSSTSPNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ GDKAKQSIRA KCTEYLDRAE KLKEYLKNKE KKAQKPVKEG QPSPADEKGN DSDGEGESDD PEKKKLQNQL QGAIVIERPN VKWSDVAGLE GAKEALKEAV ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK SYLAKAVATE ANNSTFFSIS SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC GSRSENESEA ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL PEPHARAAMF KLHLGTTQNS LTEADFRELG RKTDGYSGAD ISIIVRDALM QPVRKVQSAT HFKKVRGPSR ADPNHLVDDL LTPCSPGDPG AIEMTWMDVP GDKLLEPVVS MSDMLRSLSN TKPTVNEHDL LKLKKFTEDF GQEG

Target Information

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell migration-inducing 1; Cell migration-inducing gene 1 protein; Protein SKD1; Suppressor of K(+) transport growth defect 1; suppressor of K+ transport defect 1; vacuolar protein sorting 4B; Vacuolar protein sorting-associated protein 4B

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Gene Aliases: 8030489C12Rik; MIG1; SKD1; SKD1B; VPS4-2; VPS42; VPS4B

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UniProt ID: (Human) O75351, (Mouse) P46467

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Entrez Gene ID: (Human) 9525, (Mouse) 20479, (Rat) 360834

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Function(s)
protein binding ATP binding protein C-terminus binding microtubule-severing ATPase activity ATPase activity ATPase activity, coupled identical protein binding protein homodimerization activity nucleotide binding hydrolase activity molecular_function non-motor microtubule binding protein
Process(es)
cell separation after cytokinesis potassium ion transport autophagy nucleus organization vacuole organization mitotic metaphase plate congression regulation of centrosome duplication positive regulation of G2/M transition of mitotic cell cycle protein transport endosomal transport viral life cycle viral release from host cell cholesterol transport cytoplasmic microtubule organization endosome to lysosome transport via multivesicular body sorting pathway response to lipid multivesicular body assembly viral budding via host ESCRT complex ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway positive regulation of viral process regulation of viral process protein depolymerization negative regulation of cell death late endosomal microautophagy ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway regulation of mitotic spindle assembly positive regulation of viral release from host cell negative regulation of exosomal secretion positive regulation of exosomal secretion positive regulation of centriole elongation positive regulation of viral life cycle ESCRT III complex disassembly transport endosome organization cell cycle cell division biological_process intracellular cholesterol transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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