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Kv2.2 Potassium Channel Monoclonal Antibody (N372C/51)
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FIGURE: 1 / 3
Kv2.2 Potassium Channel Antibody (75-358) in IHC (F)
Immunoblot against extracts of COS cells transiently transfected with GFP-tagged Kv2.2long, Myc-tagged Kv2.2short or untagged Kv2.1 plasmid; and adult brain membranes from rat (RBM), Kv2.2 wild-type (WT) and knockout (KO) mice probed with N372C/51 (left) or N52A/42 (right) TC supe.
Product Details
75-358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N372C/51
Immunogen
Fusion protein amino acids 717-907 (cytoplasmic C-terminus) of rat Kv2.2 long isoform (accession number Q63099) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet, alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDRK; potassium voltage gated channel, Shab-related subfamily, member 2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2
Gene Aliases: 9630047L19Rik; BB130875; Kcnb2; Kv2.2
UniProt ID: (Mouse) A6H8H5
Entrez Gene ID: (Mouse) 98741, (Rat) 117105
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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