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Invitrogen
ABCB7 Polyclonal Antibody
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Product Details
PA5-83254
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ABCB7. Recombinant protein control fragment (Product #RP-95445).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GAMKDVVKHR TSIFIAHRLS TVVDADEIIV LDQGKVAERG THHGLLANPH SIYSEMWHTQ SSRVQNHDNP KWEAKKENIS KEEERKKLQE EI
Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 87%.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter 7 protein; ATM1p; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_1; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_3; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_4; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_5; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; Iron-sulfur clusters transporter ABCB7, mitochondrial; unnamed protein product
Gene Aliases: ABC7; ABCB7; ASAT; Atm1p; EST140535
UniProt ID: (Human) O75027
Entrez Gene ID: (Human) 22
cellular iron ion homeostasis
heme transport
iron-sulfur cluster assembly
iron ion transmembrane transport
transmembrane transport
positive regulation of heme biosynthetic process
iron-sulfur cluster export from the mitochondrion
positive regulation of iron-sulfur cluster assembly
negative regulation of reactive oxygen species biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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