ADORA2B encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.
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Protein Aliases: A2b receptor; A2b, Rs; Adenosine receptor A2b; HGNC:264; netrin-1 receptor
Gene Aliases: A2b; A2BAR; A2BR; AA2BR; ADORA2; ADORA2B; AI480866; AI605384
Molecular Function: G-protein coupled receptor