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Invitrogen
CD3e Monoclonal Antibody (FN-18)
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Product Details
APS0301
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Non-human primate,
Rhesus monkey
Published species
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
FN-18
Immunogen
Rhesus monkey peripheral blood mononuclear cells.
Conjugate
Form
Lyophilized
Amount
500 µg
Purification
Ion-exchange chromatography
Storage buffer
PBS with 125mM trehalose
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitution: Dissolve the contents of the vial by injection of 0.5 mL sterile distilled water. Lyophilized product is stable for at least one year at 4°C. After reconstitution, the contents can be safely stored at 4°C for one month or for one year at -20°C.
Add 0.02% sodium azide to prevent bacterial growth.
Target Information
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD3 TCR complex; CD3 zeta chain; CD3g molecule, epsilon (CD3-TCR complex); FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor zeta chain; T-cell surface CD3 gamma chain; T3/TCR complex
Gene Aliases: CD3Z; EGK_06950; EGK_06952
Entrez Gene ID: (Rhesus monkey) 697814, (Rhesus monkey) 699582, (Rhesus monkey) 699467, (Rhesus monkey) 705270
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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