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Osenses
ASIC2 Polyclonal Antibody
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Product Details
OSA00066G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 470-503 of human ASIC2 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: ASIC2.
Target Information
ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
Gene Aliases: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNAC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2
UniProt ID: (Human) Q16515, (Rat) Q62962, (Mouse) Q925H0
Entrez Gene ID: (Human) 40, (Rat) 25364, (Mouse) 11418
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
chemical synaptic transmission
central nervous system development
peripheral nervous system development
phototransduction
sensory perception of sound
response to acidic pH
regulation of gene expression
monovalent inorganic cation transport
regulation of vasoconstriction
regulation of blood coagulation
ion transmembrane transport
regulation of ion transmembrane transport
protein localization to synapse
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of apoptotic process
sensory perception of sour taste
detection of mechanical stimulus involved in sensory perception
positive regulation of synapse assembly
cation transport
sodium ion transport
response to mechanical stimulus
cellular response to drug
cellular response to acidic pH
cation transmembrane transport
positive regulation of cation channel activity
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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