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BNIP3 Polyclonal Antibody
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Product Details
OSB00028W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the human BNIP3 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: BNIP3.
Target Information
NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B interacting protein 3; BNIP3; Hypoxia-Activated BNIP3 Overlapping Non-coding RNA; lacks exon 2; BNIP3deltaExon2; nineteen kD interacting protein-3; pro-apoptotic mitochondrial protein; unnamed protein product
Gene Aliases: BNIP3; HABON; NIP3
UniProt ID: (Human) Q12983
Entrez Gene ID: (Human) 664
mitophagy
mitophagy
response to hypoxia
apoptotic process
response to bacterium
positive regulation of autophagy
negative regulation of mitochondrial fusion
cardiac muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
negative regulation of mitochondrial membrane potential
positive regulation of macroautophagy
cerebral cortex development
mitochondrial protein catabolic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of programmed cell death
positive regulation of protein complex disassembly
mitochondrial fragmentation involved in apoptotic process
negative regulation of membrane potential
regulation of mitochondrial membrane permeability
autophagic cell death
response to axon injury
oligodendrocyte differentiation
brown fat cell differentiation
neuron apoptotic process
positive regulation of mitochondrial calcium ion concentration
defense response to virus
response to hyperoxia
reticulophagy
substrate localization to autophagosome
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
cellular response to cobalt ion
cellular response to hypoxia
reactive oxygen species metabolic process
positive regulation of mitochondrial fission
positive regulation of release of cytochrome c from mitochondria
response to oxygen-glucose deprivation
intrinsic apoptotic signaling pathway
mitochondrial outer membrane permeabilization
granzyme-mediated programmed cell death signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of mitophagy
intrinsic apoptotic signaling pathway in response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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