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Invitrogen
CABP7 Polyclonal Antibody
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FIGURE: 1 / 5
CABP7 Antibody (PA5-89372) in IHC (P)
Immunohistochemistry analysis of CABP7 in paraffin-embedded human breast cancer using. Samples were incubated with CABP7 Polyclonal antibody (Product # PA5-89372) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-89372
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human CABP7 (NP_8723331)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
21 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PKLSTSGIPE KFHGTDFDTV FWKCDMQKLT VDELKRLLYD TFCEHLSMKD IENIIMTEEE SHLGTAEECP VDVETCSNQQ I; Positive Samples: Mouse brain, Mouse lung, Mouse kidney, Rat lung, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Single-pass type IV membrane protein, perinuclear region, trans-Golgi network membrane
Target Information
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CaBP7; Calcium-binding protein 7; calcium-binding protein CaBP7; calneuron 2; Calneuron II; Calneuron-2; calneuron-II
Gene Aliases: CABP7; CALN2; rCaBP7
UniProt ID: (Human) Q86V35, (Mouse) Q91ZM8, (Rat) Q66H96
Entrez Gene ID: (Human) 164633, (Mouse) 192650, (Rat) 360970
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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