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Invitrogen
CD115 (c-fms) Monoclonal Antibody (ROS-AV170)
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FIGURE: 1 / 1
CD115 (c-fms) Antibody (MA5-28454) in IHC (F)
Immunohistochemistry analysis of CD115 (c-fms) in quail, Cortunix cortunix, bursa of Fabricius. Cryostat sections were cut from 4 week old quail bursa of Fabricius. Clone ROS-AV170 specifically stains the bursal secretory dendritic cells located in the medulla and the macrophages of the intrafollicular connective tissue. Sample was incubated with CD115 (c-fms) monoclonal antibody (Product # MA5-28454).
Product Details
MA5-28454
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ROS-AV170
Immunogen
Purified ChCSF1R-Fc fusion protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the chicken homologue of human CSF1R, also known as CD115, CSF-1R, M-CSF receptor and c-fms. CSF1R is a single pass type 1 transmembrane protein belonging to the type III protein kinase family and is the cell surface receptor for both CSF1 and IL-34.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSFIR; EC 2.7.10.1; kinase CSFR; OTTHUMP00000224093; protein-tyrosine kinase
Entrez Gene ID: (Chicken) 396406
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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