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Invitrogen
CD142 Polyclonal Antibody
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Product Details
PA5-145607
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CD142
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
2.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VKQTYLARVF SYPAGNVEST GSAGEPLYEN SPEFTPYLET NLGQPTIQSF EQVGTKVNVT VEDERTLVRR NNTFLSLRDV FGKDLIYTLY YWKSSSSGKK TAKTNTNEFL IDVDKGEN
Target Information
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD142; coagulation factor; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); F3; TF; Thromboplastin; Tissue factor; tissue factor precursor; tissue factor versions 1 and 2 precursor; unnamed protein product
Gene Aliases: CD142; F3; TF; TFA
UniProt ID: (Human) P13726
Entrez Gene ID: (Human) 2152
positive regulation of endothelial cell proliferation
activation of plasma proteins involved in acute inflammatory response
activation of blood coagulation via clotting cascade
response to stress
blood coagulation
hemostasis
positive regulation of gene expression
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
cytokine-mediated signaling pathway
positive regulation of cell migration
positive regulation of TOR signaling
positive regulation of interleukin-8 production
positive regulation of angiogenesis
positive regulation of positive chemotaxis
positive regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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