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Proteintech
CD200 Polyclonal Antibody
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Product Details
14057-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD200 Fusion Protein Ag5045 (1-269 aa encoded by BC022522)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERLVIRMP FCHLSTYSLV WVMAAVVLCT AQVQVVTQDE REQLYTPASL KCSLQNAQEA LIVTWQKKKA VSPENMVTFS ENHGVVIQPA YKDKINITQL GLQNSTITFW NITLEDEGCY MCLFNTFGFG KISGTACLTV YVQPIVSLHY KFSEDHLNIT CSATARPAPM VFWKVPRSGI ENSTVTLSHP NGTTSVTSIL HIKDPKNQVG KEVICQVLHL GTVTDFKQTV NKGYWFSVPL LLSIVSLVIL LVLISILLYW KRHRNQDREP (1-269 aa encoded by BC022522)
Target Information
CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody MRC OX-2; CD200; CD200 antigen; OX-2 membrane glycoprotein; unnamed protein product
Gene Aliases: CD200; MOX1; MOX2; MRC; My033; OX-2
UniProt ID: (Human) P41217
Entrez Gene ID: (Human) 4345
negative regulation of leukocyte activation
negative regulation of cell proliferation
negative regulation of interleukin-6 production
heterotypic cell-cell adhesion
negative regulation of macrophage activation
positive regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
regulation of immune response
cellular response to lipopolysaccharide
cellular response to interferon-gamma
positive regulation of transforming growth factor beta production
cell-cell adhesion
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
negative regulation of matrix metallopeptidase secretion
negative regulation of macrophage migration
negative regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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