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Invitrogen
CD3 Monoclonal Antibody (MM1A)
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FIGURE: 1 / 1
CD3 Antibody (MA5-28343) in Flow
Flow cytometry of CD3 in bovine peripheral blood lymphocytes. Sample was incubated with CD3 monoclonal antibody (Product # MA5-28343). Figures are arranged as follows: A) Mouse IgG1 negative control followed by Goat anti Mouse IgG1 - PE. B) Mouse anti Bovine CD3 antibody, clone MM1A followed by Goat anti Mouse IgG1 - PE secondary antibody.
Product Details
MA5-28343
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MM1A
Immunogen
Monocyte enriched bovine mononuclear cells
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Storage buffer
tissue culture supernatant
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Bovine CD3, clone MM1A, recognizes bovine CD3.
Target Information
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; CD3 TCR complex; CD3d; CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e molecule, epsilon (CD3-TCR complex); CD3G antigen, gamma polypeptide; CD3g molecule, gamma (CD3-TCR complex); FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T3/TCR complex
Gene Aliases: CD3D; CD3E; CD3Z
UniProt ID: (Bovine) Q28072, (Bovine) Q28073
Entrez Gene ID: (Bovine) 281056, (Bovine) 281053, (Bovine) 281054, (Bovine) 281055
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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