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CD4 Polyclonal Antibody, FITC

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CD4 Polyclonal Antibody, FITC

Product Details

CD4-112-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to Human CD4 aa 437-458 (C terminal). The selected peptide was post-synthetically modified to achieve highest antigenicity before couplingto carrier protein using hetero bifunctional cross linker for Immunogen preparation.Sequence:RLLSEKKTCQCPHRFQKTCSPI
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T4 surface glycoprotein precursor; unnamed protein product; W3/25 antigen

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Gene Aliases: CD4; CD4mut; IMD79; L3T4; Leu-3; Ly-4; OKT4D; p55; T4; W3/25

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UniProt ID: (Human) P01730, (Rat) P05540, (Mouse) P06332

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Entrez Gene ID: (Human) 920, (Rat) 24932, (Mouse) 12504

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Function(s)
virus receptor activity transmembrane signaling receptor activity receptor binding extracellular matrix structural constituent protein binding zinc ion binding lipid binding coreceptor activity immunoglobulin binding enzyme binding protein kinase binding MHC class II protein complex binding signaling receptor activity interleukin-16 binding interleukin-16 receptor activity MHC class II protein binding identical protein binding protein homodimerization activity protein tyrosine kinase binding glycoprotein binding
Process(es)
cytokine production induction by virus of host cell-cell fusion immune response cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation positive regulation of protein phosphorylation adaptive immune response immune system process positive regulation of immune system process cell adhesion signal transduction enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol calcium-mediated signaling macrophage differentiation response to estradiol positive regulation of interleukin-2 production response to vitamin D positive regulation of kinase activity helper T cell enhancement of adaptive immune response interleukin-15-mediated signaling pathway positive regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade response to ethanol positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell viral entry into host cell positive regulation of multicellular organismal process regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade cellular response to granulocyte macrophage colony-stimulating factor stimulus response to methamphetamine hydrochloride cellular response to ionomycin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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