Search

  • お問い合わせ一覧​
  • クイックオーダー

Invitrogen

CD61 Polyclonal Antibody

View all (87) CD61 (Integrin beta 3) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-32889

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 14 amino acid peptide from internal region of human CD61.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550350

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (93%); Dog, Panda (86%).

For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

CD61, also known as GPIIIa or ITGB3, is a 105 kDa glycoprotein expressed on activated T cells, granulocytes, megakaryocytes, platelets, and their precursors. It plays a crucial role in platelet aggregation and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, vitronectin, and thrombospondin. CD61 forms heterodimeric complexes by associating non-covalently with integrin alpha subunits: alphaV (CD51) to create the Vitronectin Receptor and alphaIIb (CD41) to form gpIIb/IIIa. These complexes are responsible for adhesion to extracellular matrix components, facilitating cell adhesion and cell-surface mediated signaling. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, and osteoclasts in association with CD51. The protein product of CD61 is composed of an alpha chain and a beta chain, which can combine with multiple partners to form different integrins. Its involvement in cell adhesion and signaling underscores its importance in normal physiological processes. Dysfunction of CD61 is associated with diseases such as Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder, highlighting its critical role in hemostasis and platelet function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: antigen CD61; CD61; glycoprotein IIIa precursor; GPIIIa; integrin beta 3; integrin beta chain, beta 3; Integrin beta-3; integrin beta-3 subunit; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); Platelet membrane glycoprotein IIIa

View more View less

Gene Aliases: BDPLT16; BDPLT2; BDPLT24; CD61; GP3A; GPIIIa; GT; GT2; ITGB3

View more View less

UniProt ID: (Human) P05106

View more View less

Entrez Gene ID: (Human) 3690

View more View less

Function(s)
virus receptor activity fibronectin binding protease binding protein disulfide isomerase activity protein kinase C binding platelet-derived growth factor receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding enzyme binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding identical protein binding vascular endothelial growth factor receptor 2 binding metal ion binding cell adhesion molecule binding extracellular matrix binding fibrinogen binding
Process(es)
angiogenesis positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion positive regulation of leukocyte migration cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading tube development wound healing, spreading of epidermal cells response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus apolipoprotein A-I-mediated signaling pathway wound healing apoptotic cell clearance regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of transport regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation blood coagulation, fibrin clot formation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway regulation of trophoblast cell migration regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support