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Proteintech
CEP290 Polyclonal Antibody
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Product Details
22490-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CEP290 Fusion Protein Ag17457 (869-1103 aa encoded by BC008641)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Amount
76.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Two isoforms were produced by alternative splicing with predicted MW of 290 and 180 kDa according to UniProt. 22490-1-AP can recognize both.
Immunogen sequence: QMDSDEMKK ILAENSRKIT VLQVNEKSLI RQYTTLVELE RQLRKENEKQ KNELLSMEAE VCEKIGCLQR FKEMAIFKIA ALQKVVDNSV SLSELELANK QYNELTAKYR DILQKDNMLV QRTSNLEHLE CENISLKEQV ESINKELEIT KEKLHTIEQA WEQETKLGNE SSMDKAKKSI TNSDIVSISK KITMLEMKEL NERQRAEHCQ KMYEHLRTSL KQMEERNFEL ETKFAEV (869-1103 aa encoded by BC008641)
Target Information
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 14 protein; Bardet-Biedl syndrome 14 protein homolog; Cancer/testis antigen 87; centrosomal protein 290kDa; Centrosomal protein of 290 kDa; Cep290; CT87; CTCL tumor antigen se2-2; KIAA0373; MAb3H11 antigen; Meckel syndrome, type 4; monoclonal antibody 3H11 antigen; Nephrocystin-6; nephrocytsin-6; POC3 centriolar protein homolog; prostate cancer antigen T21; similar to KIAA0373 protein; Tumor antigen se2-2; unnamed protein product
Gene Aliases: 3H11Ag; b2b1454Clo; b2b1752Clo; BBS14; BC004690; CEP290; CT87; JBTS5; KIAA0373; LCA10; MKS4; NPHP6; POC3; rd16; RGD1311640; SLSN6
UniProt ID: (Human) O15078, (Mouse) Q6A078
Entrez Gene ID: (Human) 80184, (Mouse) 216274, (Rat) 314787
kidney development
protein transport
cell projection organization
hindbrain development
otic vesicle formation
eye photoreceptor cell development
camera-type eye development
positive regulation of transcription, DNA-templated
pronephros development
cilium morphogenesis
regulation of establishment of protein localization
positive regulation of intracellular protein transport
ciliary basal body-plasma membrane docking
ciliary transition zone assembly
non-motile cilium assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
establishment or maintenance of cell polarity
regulation of cAMP metabolic process
nonmotile primary cilium assembly
cilium assembly
photoreceptor cell maintenance
retina development in camera-type eye
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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