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Proteintech
peroxiredoxin 2 Monoclonal Antibody (3H6C4), CoraLite® Plus 488
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Product Details
CL488-60202
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3H6C4
Immunogen
Full length PRDX2 protein.
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calpromotin; epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; PRDX2; protector protein; PRP; Prx II-1; thiol specific antioxidant protein; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; Thioredoxin peroxidase 1; thioredoxin reductase; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; Trx dependent peroxide reductase 1; TSA; unnamed protein product
Gene Aliases: AL022839; Band-8; HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TDX1; Torin; TPx; TPx-B; TPX1; TR; TSA
UniProt ID: (Human) P32119, (Mouse) Q61171
Entrez Gene ID: (Human) 7001, (Mouse) 21672
defense response to tumor cell
respiratory burst involved in inflammatory response
response to oxidative stress
regulation of hydrogen peroxide metabolic process
removal of superoxide radicals
positive regulation of blood coagulation
negative regulation of lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
cellular response to oxidative stress
T cell proliferation
hydrogen peroxide metabolic process
hydrogen peroxide catabolic process
regulation of apoptotic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of MAPK cascade
leukocyte activation
cell redox homeostasis
negative regulation of T cell differentiation
thymus development
extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
activation of MAPK activity
negative regulation of NF-kappaB transcription factor activity
negative regulation of neuron apoptotic process
homeostasis of number of cells
oxidation-reduction process
negative regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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