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Proteintech
TLE1 Monoclonal Antibody (2F2H11), CoraLite® Plus 488
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Product Details
CL488-66216
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2F2H11
Immunogen
TLE1 fusion protein Ag21327
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DPPPHMRVPT IPPNLAGIPG GKPAYSFHVT ADGQMQPVPF PPDALIGPGI PRHARQINTL NHGEVVCAVT ISNPTRHVYT GGKGCVKVWD ISHPGNKSPV SQLDCLNRDN YIRSCKLLPD GCTLIVGGEA STLSIWDLAA PTPRIKAELT SSAPACYALA ISPDSKVCFS CCSDGNIAVW DLHNQTLVRQ FQGHTDGASC IDISNDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW LAVGMESSNV EVLHVNKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL LNAWRTPYGA SIFQSKESSS VLSCDISVDD KYIVTGSGDK KATVYEVIY
Target Information
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; RP11-203D19.1; TLE 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transducin-like enhancer protein 1; unnamed protein product
Gene Aliases: ESG; ESG1; GRG1; TLE-1; TLE1
UniProt ID: (Human) Q04724
Entrez Gene ID: (Human) 7088
regulation of transcription, DNA-templated
signal transduction
organ morphogenesis
positive regulation of gene expression
Wnt signaling pathway
negative regulation of Wnt signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
negative regulation of anoikis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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