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CYP2E1 Monoclonal Antibody (1F12G7), CoraLite® Plus 488

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Product Details

CL488-67263

Applications
Tested Dilution
Publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500
-

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1F12G7

Immunogen

Peptide

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 4-nitrophenol 2-hydroxylase; CP2E1; CYPIIE1; Cytochrome P-450-J; Cytochrome P450 2E1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-ALC; Cytochrome P450-J; cytochrome P450A; cytochrome P450j; Cytochrome P450RLM6; flavoprotein-linked monooxygenase; microsomal monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase; P450-J; P450RLM6; unnamed protein product; xenobiotic monooxygenase

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Gene Aliases: CPE1; CYP2E; Cyp2e-1; CYP2E1; P450-J; P450C2E

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UniProt ID: (Human) P05181, (Pig) P79383, (Mouse) Q05421, (Rat) P05182

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Entrez Gene ID: (Human) 1571, (Pig) 403216, (Mouse) 13106, (Rat) 25086

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Function(s)
monooxygenase activity iron ion binding arachidonic acid epoxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4-nitrophenol 2-monooxygenase activity oxygen binding enzyme binding heme binding Hsp70 protein binding metal ion binding Hsp90 protein binding long-chain fatty acid omega-1 hydroxylase activity aromatase activity steroid hydroxylase activity 3-(3-hydroxyphenyl)propionate hydroxylase activity 4-chlorobenzaldehyde oxidase activity 3,5-xylenol methylhydroxylase activity phenylacetate hydroxylase activity 4-nitrophenol 4-monooxygenase activity dimethyl sulfide monooxygenase activity alpha-pinene monooxygenase [NADH] activity phenanthrene 9,10-monooxygenase activity 1-hydroxy-2-naphthoate hydroxylase activity toluene 4-monooxygenase activity xylene monooxygenase activity dibenzothiophene monooxygenase activity 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity chlorophenol 4-monooxygenase activity carbon disulfide oxygenase activity toluene 2-monooxygenase activity 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity phenanthrene 1,2-monooxygenase activity tetrahydrofuran hydroxylase activity styrene monooxygenase activity toluene-4-sulfonate monooxygenase activity toluene-sulfonate methyl-monooxygenase activity 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 2-hydroxy-phenylacetate hydroxylase activity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity phenanthrene 3,4-monooxygenase activity toluene 3-monooxygenase activity 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity limonene monooxygenase activity 2-methylnaphthalene hydroxylase activity 1-methylnaphthalene hydroxylase activity bisphenol A hydroxylase A activity salicylate 5-hydroxylase activity isobutylamine N-hydroxylase activity branched-chain dodecylbenzene sulfonate monooxygenase activity 3-HSA hydroxylase activity 4-hydroxypyridine-3-hydroxylase activity 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity 6-hydroxynicotinate 3-monooxygenase activity tocotrienol omega-hydroxylase activity thalianol hydroxylase activity FMN binding oxidoreductase oxygenase metabolite interconversion enzyme
Process(es)
long-chain fatty acid metabolic process lipid hydroxylation lipid metabolic process fatty acid metabolic process xenobiotic metabolic process steroid metabolic process response to bacterium monoterpenoid metabolic process carbon tetrachloride metabolic process benzene metabolic process 4-nitrophenol metabolic process epoxygenase P450 pathway halogenated hydrocarbon metabolic process long-chain fatty acid biosynthetic process oxidation-reduction process triglyceride metabolic process drug metabolic process exogenous drug catabolic process heterocycle metabolic process response to ozone response to organonitrogen compound response to drug response to ethanol
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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