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Proteintech
USP8 Monoclonal Antibody (1E12E3), CoraLite® Plus 488
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Product Details
CL488-67321
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E12E3
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SSLKDLNKKT EVKPEKISTK SYVHSALKIF KTAEECRLDR DEERAYVLYM KYVTVYNLIK KRPDFKQQQD YFHSILGPGN IKKAVEEAER LSESLKLRYE EAEVRKKLEE KDRQEEAQRL QQKRQETGRE DGGTLAKGSL ENVLDSKDKT QKSNGEKNEK CETKEKGAIT AKELYTMMTD KNISLIIMDA RRMQDYQDSC ILHSLSVPEE AISPGVTASW IEAHLPDDSK DTWKKRGNV
Target Information
USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 8; hUBPy; KIAA0055; mUBPy; putative deubiquitinating enzyme; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8; unnamed protein product
Gene Aliases: AI574262; AW557536; HumORF8; KIAA0055; mKIAA0055; PITA4; SPG59; UBPY; USP8
UniProt ID: (Human) P40818, (Mouse) Q80U87
Entrez Gene ID: (Human) 9101, (Mouse) 84092
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
SH3 domain binding
cadherin binding
Lys63-specific deubiquitinase activity
Lys48-specific deubiquitinase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
mitotic cytokinesis
proteolysis
endosome organization
Ras protein signal transduction
protein deubiquitination
regulation of protein stability
regulation of protein localization
protein K63-linked deubiquitination
protein K48-linked deubiquitination
cellular response to dexamethasone stimulus
positive regulation of canonical Wnt signaling pathway
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
negative regulation of lysosomal protein catabolic process
positive regulation of amyloid fibril formation
cellular response to nerve growth factor stimulus
ubiquitin-dependent protein catabolic process
cell cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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