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Proteintech
YWHAZ Monoclonal Antibody (3G12B10), CoraLite® Plus 488
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Product Details
CL488-67698
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
3G12B10
Immunogen
YWHAZ fusion protein Ag6667
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Caprylic acid precipitation, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDKNELVQK AKLAEQAERY DDMAACMKSV TEQGAELSNE ERNLLSVAYK NVVGARRSSW RVVSSIEQKT EGAEKKQQMA REYREKIETE LRDICNDVLS LLEKFLIPNA SQAESKVFYL KMKGDYYRYL AEVAAGDDKK GIVDQSQQAY QEAFEISKKE MQPTHPIRLG LALNFSVFYY EILNSPEKAC SLAKTAFDEA IAELDTLSEE SYKDSTLIMQ LLRDNLTLWT SDTQGDEAEA GEGGEN
Target Information
At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 delta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 1433Z; 143Z; epididymis luminal protein 4; epididymis secretory protein Li 3; epididymis secretory protein Li 93; KCIP-1; Mitochondrial import stimulation factor S1 subunit; phospholipase A2; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; SEZ-2; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; unnamed protein product
Gene Aliases: 1110013I11Rik; 14-3-3-zeta; 14-3-3z; 14-3-3zeta; AI596267; AL022924; AU020854; HEL-S-3; HEL-S-93; HEL4; KCIP-1; Msfs1; POPCHAS; YWHAD; YWHAZ
UniProt ID: (Human) P63104, (Mouse) P63101, (Rat) P63102
Entrez Gene ID: (Human) 7534, (Mouse) 22631, (Rat) 25578
RNA binding
protein binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
ubiquitin protein ligase binding
identical protein binding
ion channel binding
cadherin binding
phosphoserine binding
DNA-binding transcription factor binding
protein sequestering activity
transcription factor binding
protein complex binding
poly(A) RNA binding
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
respiratory system process
protein phosphorylation
protein targeting
lysosome organization
signal transduction
synaptic target recognition
protein localization
lung development
regulation of protein stability
cellular response to nutrient levels
tube formation
TORC1 signaling
cellular response to glucose starvation
negative regulation of apoptotic process
regulation of programmed cell death
negative regulation of innate immune response
establishment of Golgi localization
ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade
regulation of synapse maturation
Golgi reassembly
antibacterial innate immune response
negative regulation of protein localization to nucleus
negative regulation of TORC1 signaling
regulation of lysosome organization
histamine secretion by mast cell
protein targeting to mitochondrion
regulation of cell death
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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