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KDM1B Monoclonal Antibody (1E1A3), CoraLite® Plus 488
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FIGURE: 1 / 1
KDM1B Antibody (CL488-67886) in Flow
1X10^6 SW 1990 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-HUMAN KDM1B (CL488-67886, Clone:1E1A3) (red), or 0.4 µg Control Antibody. Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67886
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E1A3
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: FPYRFWDSKV QGADFFGHVP PSASKRGLFA VFYDMDPQKK HSVLMSVIAG EAVASVRTLD DKQVLQQCMA TLRELFKEQE VPDPTKYFVT RWSTDPWIQM AYSFVKTGGS GEAYDIIAED IQGTVFFAGE ATNRHFPQTV TGAYLSGVRE ASKIAAF
Target Information
The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; Flavin-containing amine oxidase domain-containing protein 1; lysine (K)-specific demethylase 1B; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2; unnamed protein product
Gene Aliases: 4632428N09Rik; AI482520; AOF1; C6orf193; KDM1B; LSD2
UniProt ID: (Human) Q8NB78, (Mouse) Q8CIG3
Entrez Gene ID: (Human) 221656, (Mouse) 218214, (Rat) 306819
protein binding
zinc ion binding
oxidoreductase activity
histone demethylase activity
histone demethylase activity (H3-K4 specific)
histone binding
metal ion binding
flavin adenine dinucleotide binding
FAD binding
FAD-dependent H3K4me/H3K4me3 demethylase activity
DNA binding
N-ethylmaleimide reductase activity
histone demethylase activity (H3-trimethyl-K4 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
histone demethylase activity (H3-monomethyl-K4 specific)
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
epoxyqueuosine reductase activity
molecular_function
oxidase
oxidoreductase
metabolite interconversion enzyme
chromatin organization
regulation of gene expression, epigenetic
protection of DNA demethylation of female pronucleus
positive regulation of gene expression, epigenetic
genetic imprinting
regulation of gene expression by genetic imprinting
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
histone H3-K4 demethylation
DNA methylation involved in gamete generation
regulation of DNA methylation
oxidation-reduction process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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