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Proteintech
DUSP22 Monoclonal Antibody (3B8F1), CoraLite® Plus 488
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Product Details
CL488-68032
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3B8F1
Immunogen
DUSP22 fusion protein Ag9831
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MGNGMNKIL PGLYIGNFKD ARDAEQLSKN KVTHILSVHD SARPMLEGVK YLCIPAADSP SQNLTRHFKE SIKFIHECRL RGESCLVHCL AGVSRSVTLV IAYIMTVTDF GWEDALHTVR AGRSCANPNV GFQRQLQEFE KHEVHQYRQW LKEEYGESPL QDAEEAKNIL AAPGILKFWA FLRRL
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586F2224; Dual specificity protein phosphatase 22; dual-specificity phosphatase; epididymis secretory sperm binding protein; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK pathway associated phosphatase; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; Mitogen-activated protein kinase phosphatase x; PYST2; unnamed protein product
Gene Aliases: DUSP22; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
UniProt ID: (Human) Q9NRW4, (Mouse) Q99N11
Entrez Gene ID: (Human) 56940, (Rabbit) 100353877, (Mouse) 105352, (Rat) 361242
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
hydrolase activity
protein tyrosine kinase inhibitor activity
protein tyrosine kinase binding
protein binding
phosphatase activity
protein phosphatase
negative regulation of transcription from RNA polymerase II promoter
immune system process
negative regulation of T cell mediated immunity
negative regulation of cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
negative regulation of cell migration
intracellular signal transduction
regulation of cell proliferation
positive regulation of JNK cascade
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
negative regulation of T cell activation
negative regulation of focal adhesion assembly
protein K63-linked ubiquitination
protein K48-linked ubiquitination
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
protein dephosphorylation
dephosphorylation
peptidyl-tyrosine dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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