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Proteintech
UBE2D1/2/3/4 Monoclonal Antibody (1C7D12), CoraLite® Plus 488
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Product Details
CL488-68138
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C7D12
Immunogen
UBE2D1/2/3/4 fusion protein Ag2278
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MALKRINKE LSDLARDPPA QCSAGPVGDD MFHWQATIMG PNDSPYQGGV FFLTIHFPTD YPFKPPKVAF TTRIYHPNIN SNGSICLDIL RSQWSPALTI SKVLLSICSL LCDPNPDDPL VPEIARIYKT DRDKYNRISR EWTQKYAM
Target Information
Ubiquitination is a post-translational modification pathway or is part of the specific protein-degradation pathway by the 26S proteasome. Ubiquitination of a target protein involves multistep enzymatic reaction catalyzed by a cascade of enzymes including Ub-activating enzymes (E1s), Ub-conjugating enzymes (E2s) and Ub ligases (E3s) (PMID: 23542885). UBE2D family, which has 4 members named as UBE2D1/2/3/4, is an E2 ubiquitin-conjugating enzyme family in the ubiquitin-proteasome system. This antibody can recognize all the four members of UBE2D due to the high homology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme D1; (E3-independent) E2 ubiquitin-conjugating enzyme D2; (E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2B; E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D4; E2(17)KB 1; E2(17)KB 2; E2(17)KB 2B; E2(17)KB 3; HBUCE1; p53-regulated ubiquitin-conjugating enzyme 1; PAPase; Phosphoarginine phosphatase; predicted protein of HQ2116; SFT; similar to UBC4/5 in yeast; Stimulator of Fe transport; ubc2e ubiquitin conjugating enzyme; UBC4/5 homolog; UbcH5; UBE2D1/UBE2D3/UBE2D3/UBE2D4; UBE2D3; Ubiquitin carrier protein D1; Ubiquitin carrier protein D2; Ubiquitin carrier protein D2B; Ubiquitin carrier protein D3; Ubiquitin carrier protein D4; ubiquitin conjugating enzyme E2 D4 (putative); ubiquitin conjugating enzyme E2D 1; ubiquitin conjugating enzyme E2D 2; ubiquitin conjugating enzyme E2D 3; ubiquitin conjugating enzyme E2D 4 (putative); Ubiquitin-conjugating enzyme E2 D1; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin-conjugating enzyme E2 D2B; Ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2 D4; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2(17)KB 2B; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-conjugating enzyme E2-17 kDa 2B; Ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme HBUCE1; Ubiquitin-protein ligase D1; Ubiquitin-protein ligase D2; Ubiquitin-protein ligase D2B; Ubiquitin-protein ligase D3; Ubiquitin-protein ligase D4; unnamed protein product
Gene Aliases: 1100001F19Rik; 9430029A22Rik; AA414951; E2(17)KB1; E2(17)KB2; E2(17)KB3; E217kB; HBUCE1; PUBC1; RGD69425; SFT; Ubc2e; UBC4; UBC4/5; UBC5A; UBC5B; UBC5C; UBCH4; UBCH5; UBCH5A; UBCH5B; UBCH5C; UBCH5D; UBE2D1; UBE2D2; Ube2d2b; UBE2D3; UBE2D4
UniProt ID: (Human) P51668, (Human) P62837, (Human) P61077, (Human) Q9Y2X8, (Mouse) P61080, (Rat) D3ZDK2, (Rat) P62839, (Mouse) P61079, (Rat) P61078, (Rat) P70711
Entrez Gene ID: (Human) 7321, (Human) 7322, (Human) 7323, (Human) 51619, (Mouse) 216080, (Rat) 361831, (Rat) 641452, (Mouse) 66105, (Rat) 81920, (Rat) 79435
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein ubiquitination
negative regulation of BMP signaling pathway
positive regulation of protein ubiquitination
cellular response to nutrient levels
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked ubiquitination
positive regulation of protein polyubiquitination
negative regulation of TORC1 signaling
protein modification process
protein autoubiquitination
DNA repair
protein monoubiquitination
apoptotic process
cellular response to DNA damage stimulus
protein K11-linked ubiquitination
protein K6-linked ubiquitination
positive regulation of protein targeting to mitochondrion
protein K29-linked ubiquitination
protein K27-linked ubiquitination
protein K63-linked ubiquitination
metabolic process
biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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