Search

  • Fale Conosco
  • Pedido rápido

Proteintech

TSC2 Monoclonal Antibody (1A10B2), CoraLite® Plus 488

View all (50) TSC2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

CL488-68380

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A10B2

Immunogen

Peptide

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: OTTHUMP00000198394; protein phosphatase 1, regulatory subunit 160; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis 2 protein homolog; tuberous sclerosis complex locus 2; unnamed protein product

View more View less

Gene Aliases: LAM; Nafld; PPP1R160; Tcs2; TSC2; TSC4

View more View less

UniProt ID: (Human) P49815

View more View less

Entrez Gene ID: (Human) 7249, (Mouse) 22084

View more View less

Function(s)
GTPase activator activity protein binding phosphatase binding small GTPase binding protein homodimerization activity Hsp90 protein binding protein heterodimerization activity 14-3-3 protein binding GTPase-activating protein
Process(es)
neural tube closure cytoplasmic translation protein import into nucleus endocytosis heart development protein localization negative regulation of cell proliferation cellular response to starvation vesicle-mediated transport positive regulation of macroautophagy regulation of macroautophagy regulation of endocytosis negative regulation of Wnt signaling pathway cellular response to nutrient levels negative regulation of TOR signaling TORC1 signaling anoikis negative regulation of translational initiation positive regulation of translational initiation regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway positive chemotaxis regulation of small GTPase mediated signal transduction regulation of cell cycle negative regulation of protein kinase B signaling negative regulation of macromitophagy negative regulation of TORC1 signaling positive regulation of TORC1 signaling response to hypoxia negative regulation of protein kinase activity signal transduction phosphatidylinositol 3-kinase signaling negative regulation of phosphatidylinositol 3-kinase signaling cell projection organization cellular response to insulin stimulus negative regulation of MAP kinase activity protein kinase B signaling positive regulation of GTPase activity protein transport into plasma membrane raft establishment of protein localization negative regulation of cell size positive regulation of transcription from RNA polymerase II promoter glucose import insulin-like growth factor receptor signaling pathway negative regulation of epithelial cell proliferation protein homooligomerization protein heterooligomerization
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support