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OGT Recombinant Rabbit Monoclonal Antibody (230385D11), CoraLite® Plus 488

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OGT Recombinant Rabbit Monoclonal Antibody (230385D11), CoraLite® Plus 488

Product Details

CL488-83113

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

230385D11

Immunogen

OGT fusion protein Ag2160
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MASSVGNVAD STGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKAVTL DPNFLDAYIN LGNVLKEARI FDRAVAAYLR ALSLSPNHAV VHGNLACVYY EQGLIDLAID TYRRAIELQP HFPDAYCNLA NALKEKGSVA EAEDCYNTAL RLCPTHADSL NNLANIKREQ GNIEEAVRLY RKALEVFPEF AAAHSNLASV LQQQGKLQEA LMHYKEAIRI SPTFADAYSN MGNTLKEMQD

Target Information

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23071; MGC22921; O linked N-acetylglucosamine transferase; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; unnamed protein product; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase

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Gene Aliases: 1110038P24Rik; 4831420N21Rik; AI115525; HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT; OGT1; Ogtl; XLID106

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UniProt ID: (Human) O15294, (Mouse) Q8CGY8, (Rat) P56558

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Entrez Gene ID: (Human) 8473, (Mouse) 108155, (Rat) 26295

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Function(s)
protein binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding acetylglucosaminyltransferase activity transferase activity transferase activity, transferring glycosyl groups chromatin DNA binding protein O-GlcNAc transferase activity catalytic activity enzyme activator activity N-acetyltransferase activity transcription factor binding protein N-acetylglucosaminyltransferase activity protein domain specific binding peptide binding histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific) monosaccharide binding protein modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter mitophagy positive regulation of transcription from RNA polymerase II promoter by glucose cytoplasmic translation regulation of glycolytic process regulation of gluconeogenesis chromatin organization regulation of transcription from RNA polymerase II promoter protein glycosylation protein O-linked glycosylation apoptotic process signal transduction response to nutrient protein processing negative regulation of translation hemopoiesis negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein ubiquitination cellular response to nutrient levels negative regulation of proteasomal ubiquitin-dependent protein catabolic process response to insulin circadian regulation of gene expression regulation of Rac protein signal transduction TORC1 signaling positive regulation of translation positive regulation of proteolysis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of translational initiation positive regulation of translational initiation regulation of insulin receptor signaling pathway positive regulation of lipid biosynthetic process rhythmic process protein maturation regulation of synapse assembly regulation of necroptotic process protein localization to lysosome pyroptosis cellular response to glucose stimulus regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of cold-induced thermogenesis membraneless organelle assembly non-canonical inflammasome complex assembly negative regulation of non-canonical inflammasome complex assembly negative regulation of stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of TORC1 signaling negative regulation of protein phosphorylation positive regulation of protein phosphorylation glucosamine metabolic process positive regulation of gene expression negative regulation of peptidyl-threonine phosphorylation chromatin modification positive regulation of granulocyte differentiation negative regulation of peptidyl-serine phosphorylation positive regulation of catalytic activity histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation positive regulation of cell size phosphatidylinositol-mediated signaling intracellular distribution of mitochondria positive regulation of histone H3-K4 methylation negative regulation of cell death positive regulation of histone H3-K27 methylation protein homotrimerization protein heterotrimerization cellular response to lipopolysaccharide cellular response to retinoic acid histone H3-K4 trimethylation negative regulation of protein targeting to membrane regulation of gluconeogenesis involved in cellular glucose homeostasis negative regulation of cellular response to hypoxia positive regulation of protein localization to nucleus positive regulation of reactive oxygen species biosynthetic process forebrain development cellular response to insulin stimulus cellular response to toxic substance
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